Mosquito bites are caused by the body’s reaction to protein components of the saliva a mosquito injects under the skin when it feeds. Infrequently, people can become sensitized to mosquito bites and respond with an immune reaction much more intense that a typical bite. Within hours to days of the bite, a large portion of the skin surrounding the bite turns red. A bite can cause more systemic symptoms such as a swollen limb and watery eyes.
Skeeter syndrome can develop suddenly. This phenomena may be explained if the allergy is only to saliva from a mosquito species that bites infrequently. When the allergic person is bit by this species of mosquito, a hyper allergic response is elicited. A mosquito bite can come from one of dozens of mosquito species. If most bites come from non-allergenic mosquitoes, then a hyper allergic reaction will not be elicited.